Effetti della melatonina sull'impianto osseoEffect of FGF-2 and melatonin on implant bone healing: a histomorphometric study.Department of Oral and Maxillofacial Surgery, Division of Cervico Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3 Minami-ku, Hiroshima, 734-8553, Japan, takechi@hiroshima-u.ac.jp. Takechi M, Tatehara S, Satomura K, Fujisawa K, Nagayama M. Melatonin influences the release of growth hormone and cortisol in humans, and it was recently reported that it promoted bone formation. On the other hand, fibroblast growth factor-2 (FGF-2) was reported to facilitate the proliferation of osteoblasts. In the present study, we examined the effect of recombinant human FGF-2 and melatonin on the promotion of osteogenesis around titanium implants. Twenty-four 10-week-old female rats of the Wistar strain received titanium implants in both tibiae. In the experimental groups, 100 mg/kg body weight of melatonin was administered by intraperitoneal injection for 4 weeks after implantation and 10 mug of FGF-2 was locally injected around the implant sites 5 days after implantation. The control groups were administered saline only. In the control group, few newly formed bone could be seen around the implants. It was observed to be in direct contact with the implant surface, but otherwise unmineralized connective tissue was occasionally interposed. In the experimental group, newly formed bone was observed around the titanium implant. In addition, in contrast to the control group, abundant bone trabeculae were seen in the medullary canal region. Bone trabeculae were directly connected to existing cortical bone. These results strongly suggested that melatonin and FGF-2 have the potential to promote osseointegration. PMID: 18360797 [PubMed - as supplied by publisher] Visita il sito internet www.melatonina.it Melatonina contro la depressione stagionale Studio sulla Melatonina e insufficienza renale cronica Melatonina riduce l'infiammazione renale interstiziale e migliora l'ipertensione e ratti spontaneamente ipertesi Effetti della melatonina in menopausa Effetti della melatonina sull'impianto osseo Melatonina in Dermatologia Melatonina e insofferenza renale cronaca Melatonina l'ormone dell'oscurità Alopecia, un aiuto dalla melatonina? adolescenti come 'uccelli notturni' lo decide orologio interno Study bolsters melatonin sleep claims Melatonin elevates HDL in peri- and postmenopausal women Melatonin and the Thyroid Gland Delayed Sleep Phase Syndrome: A Melatonin Onset Disorder Heterologous Modulation of Androgen Receptor Nucleo-Cytoplasmic Shuttling by Melatonin: A Novel Mode of Regulating Androgen Sensitivity The Role of Thermoregulation in the Soporific Effects of Melatonin: A New Perspective Clinical Utility of the Antioxidant Melatonin in the Newborn The Role of Melatonin in the Development of Scoliosis Extrapineal Melatonin: Location and Role in Pathological Processes Melatonin in Winter Depression Cardiovascular Effects of Melatonin |
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